neuropathic pain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22360	MDR-652		TRP/TRPV Channel
	MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ...		TRP/TRPV Channel
T4S0537	Neoline	Bullatine B	Others
	Neoline (Bullatine B) shows analgesic/anti-inflammatory properties.		Others
T8975	PSB-SB-487		Cannabinoid Receptor
	PSB-SB-487 is antagonist of GPR55.		Cannabinoid Receptor
T16164	MY-5445	N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).		PDE
T4298	JNJ-47965567	JNJ-479655	P2X Receptor
	JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).		P2X Receptor
T16014	Mavatrep	JNJ-39439335	TRP/TRPV Channel
	Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.		TRP/TRPV Channel
TQ0002	A-317491	ABT 202	P2X Receptor
	A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.		P2X Receptor
T0386L	Ropivacaine	LEA-103 HCl	Potassium Channel , Sodium Channel
	Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.		Potassium Channel , Sodium Channel
T7748	Dermorphin TFA		Others , Opioid Receptor
	Dermorphin TFA is a new class of opioids-like peptides		Others , Opioid Receptor
T21980	PD 198306		MEK
	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.		MEK
T7416	WS-12		TRP/TRPV Channel
	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)		TRP/TRPV Channel
T0386	Ropivacaine hydrochloride	Ropivacaine monohydrochloride	Potassium Channel , Sodium Channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.		Potassium Channel , Sodium Channel
T23008L	MMPIP hydrochloride	MMPIP hydrochloride (479077-02-6 Free base)	GluR
	MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.		GluR
T3026	(-)-Huperzine A	HupA,Huperzine A	Apoptosis , AChR , AChE , iGluR
	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...		Apoptosis , AChR , AChE , iGluR
T8579	Nav1.8-IN-1	5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208	Sodium Channel
	Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8		Sodium Channel
T8333	Aurintricarboxylic acid	ATA,NSC-4056,NSC4056,NSC 4056	Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.		Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
T7705	GW 405833	L-768242	Cannabinoid Receptor
	GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective		Cannabinoid Receptor
T29112	VPC171	VPC 171,VPC-171	Adenosine Receptor
	VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).		Adenosine Receptor
T3280	Clodronate disodium tetrahydrate	clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium	IL Receptor , TNF
	Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.		IL Receptor , TNF
T0678	Amitriptyline hydrochloride	Amitriptyline HCl,Tryptizol,Domical,Annoyltin	Trk receptor , Sigma receptor , 5-HT Receptor , Serotonin Transporter , Sodium Channel , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.